The controlled release formulations like solid dosage forms, semi-solid dosage forms, and topical preparations have more importance in pharmaceutical industry due to their efficacy and patient compliance. The topical preparations are supposed to work on the surface of the skin. After application on skin these formulation releases their active ingredient and causes the accumulation of active ingredient which is quickly absorbed. This accumulation causes irritation of skin and high concentration of actives in the circulation. Thus, the microsponge delivery system is an approach to increase the amount of time that an active ingredient remains present either on skin or within the epidermis, which minimizes the transdermal penetration of drug. Microsponges are micro-porous polymeric bead which are loaded with an active ingredient. This system can be incorporated in dosage forms such as creams, lotions, ointments, gels, powders and recently in tablets.
Loading....